Sep 16, 20 the gastrointestinal tract is the predominant site of appearance of extranodal nonhodgkin lymphomas. Multiple lymphomatous polyposis is considered to be a rare condition, with most of the cases being extranodal counterpart of mantle cell lymphomas. Sep 22, 2016 multiple lymphomatous polyposis mlp is uncommon and is regarded as the intestinal form of mcl. These findings confirmed the diagnosis of multiple lymphomatous polyposis of the gastrointestinal tract, which was first proposed by cornes in 1961. The subsequent workup included a thoracoabdominopelvic computed tomography ct scan that revealed thickening of several segments of the small and large intestinal walls, most prominent in the terminal ileum, multiple mesenteric adenopathies and homogeneous hepatosplenomegaly. Multiple lymphomatous polyposis originates from the mantle zone of the lymphoma follicle and is considered to be a mantle cell lymphoma, which is a relatively aggressive type of bcell nonhodgkins lymphoma. Only 4% of intestinal lymphomas result in polyposis. We report an unusual case of a patient with multiple. We report two rare cases of multiple lymphomatous polyposis of the gastrointestinal tract. In addition, immunohistochemical analysis of the biopsy tissues demonstrated positive staining for cd20, cd5, bcl 2, cd43 and mantle cell lymphoma with multiple lymphomatous polyposis and intussusception. Multiple lymphomatous polyposis of the intestine with ileocecal. There were multiple widespread polypoid lesions in the entire gastrointestinal tract, with ileocecal masses. Pdf multiple lymphomatous polyposis ibrahim arslan. Multiple lymphomatous polyposis of the intestine with.
Mantle cell lymphoma presenting as multiple lymphomatous. Multiple lymphomatous polyposis may also be seen in marginal b cell lymphomas, mucosa associated lymphoid tissue malt, and follicular lymphomas. Endoscopic mucosal resections were performed on lesions and the resected specimens suggested mantle cell lymphoma mcl. Multiple lymphomatous polyposis mlp is an uncommon disease that is regarded as the gastrointestinal form of mcl. Pdf multiple lymphomatous polyposis mustafa benekli.
Despite prompt remission, prognosis remains poor in view of increased relapse rates. Multiple polypoid masses of the distal ileum were identified in the right hemicolectomy specimen multiple lymphomatous polyposis. The aim of this study was to analyze the clinicopathologic features and outcome of a large series of patients. The differential diagnoses of multiple lymphomatous polyposis includes adenomatous polyps, with or without carcinomatous degeneration, familial polyposis and syndromes of peutzjeghers and nodular. Saito m, izumiyama k, ogasawara r, mori a, kondo t, tanaka m, morioka m, miyashita k, tanino m.
From 1984 to 1995, 31 patients were enrolled prospectively. A unique presentation of primary intestinal malt lymphoma. Clinical features, family history, and histology usually distinguish these conditions. Primary nonhodgkins lymphoma nhl of the gastrointestinal gi tract is the most common extranodal nhl and accounts for 4%20% of all nhl.
Multiple lymphomatous polyposis definition of multiple. It is characterized by a particular involvement of the gastrointestinal tract in which long segments are the location of numerous. Multiple lymphomatous polyposis is a distinctive and particularly rare clinical type of malignant gastrointestinal lymphoma, which is classified as bcell centrocytic nonhodgkins lymphoma. The histopathology in both cases was diffuse poorly differentiated lymphoma. Alkpositive anaplastic large cell lymphoma presenting multiple lymphomatous polyposis. A rare case of multiple lymphomatous polyposis with widespread. Mantlecell lymphoma multiple lymphomatous polyposis. Sep 10, 2014 the ileocecal region is the commonest site involved. Multiple polypoid masses of the distal ileum were identified in the right hemicolectomy. Multiple biopsies of the complete gi tract presented diffuse infiltration of monotonous smalltomedium sized, lymphoid cells.
This rare entity has been recently reclassified as mantle cell lymphoma. Colonoscopy with multiple polypoid lesions ranging from 0. Multiple lymphomatous polyposis of the gastrointestinal. A patient with this condition who achieved a complete remission with combination chemotherapy is reported. Multiple lymphomatous polyposis mlp is an uncommon type of primary nonhodgkin gastrointestinal gi bcell lymphoma characterized by the presence of multiple polyps along the gi tract. Lymphomatous definition of lymphomatous by medical.
There was no particular history except an episode of upper gi ugi bleeding 25 years ago. Multiple lymphomatous polyposis overexpressing cyclin d1. Multiple lymphomatous polyposis was detected by endoscopy. However, multiple lymphomatous polyposis is an uncommon. Multiple lymphomatous polyposis mlp is thought to be a typical form of gastrointestinal lesion in mantle cell lymphoma, but it develops in other bcell lymphomas. Primary gastrointestinal tcell lymphoma resembling multiple. Multiple lymphomatous polyposis is a specific type of lymphomas. A unique presentation of primary intestinal malt lymphoma as.
Multiple intestinal lymphomatous polyposis in a jindo dog. Mantle cell lymphoma with multiple lymphomatous polyposis. Gastrointestinal multiple lymphomatous polyposis is a rare type of malignant lymphoma that has aggressive biological behavior, early. A second colonoscopic examination performed in july 2004 revealed increased numbers of polyps, indicating a case of multiple lymphomatous polyposis mlp. Mantle cell lymphoma mcl has tropism for the gastrointestinal tract git identifiable as multiple polyps and mass lesions throughout the git.
A rare case of multiple lymphomatous polyposis with. Multiple lynphomatous polyposis is a type of appearance of mantle cell lymphoma. Approximately 60 cases of mlp have been reported so far. Gi symptoms include pain, obstruction, diarrhea, or hematochezia.
A study of four cases of mlp has shown a tendency for ileocaecal involvement and extra. We report the first case of diffuse large bcell lymphoma presenting as multiple lymphomatous polyposis of the gi tract in a 49yearold patient with hiv and describe the clinicopathologic features. Pathology outlines mantle cell lymphoma, classic variant. Multiple lymphomatous polyposis and the role of fine. It is characterized by multiple polypoid lesions involving long gastrointestinal tracts and it accounts for only approximately 12% of nonhodgkin lymphomas.
Multiple lymphomatous diverticulosis and comorbid chronic. Gastrointestinal multiple lymphomatous polyposis is a rare type of malignant lymphoma that has aggressive biological behavior, early systemic. Pdf colonic mantle cell lymphoma with multiple lymphomatous. Histologically, benign lymphoid hyperplasia is the entity most likely to be confused with lymphomatous polyposis. Mantlecell lymphoma multiple lymphomatous polyposis of the entire gi tract a 65yearold white man was admitted at to the emergency room with melena of moderate severity in may 2005. Alkpositive anaplastic large cell lymphoma presenting. A 60yearold woman with known chronic lymphocytic leukemia cll had an exophytic mass of the appendiceal orifice. The ileocecal region is the commonest site involved. Multiple lymphomatous polyposis of the gastrointestinal tract multiple lymphomatous polyposis of the gastroin testinal tract has been reported rarely. A micronodular pattern of splenic involvement are seen in both mantle cell lymphoma and splenic marginal zone lymphoma villous cells in pb may be seen in mantle cell lymphoma mantle cell lymphoma expresses cd5 and cyclin d1. A rare presentation of multiple lymphomatous polyposis with.
We present a typical case diagnosed by using an intestinal barium followthrough and ct scan which revealed gastric, ileac and colonic involvement as well as retroperitoneal. The lymphoma is of centrocytic type and exhibits a nodular pattern of. Meeting abstract open access multiple lymphomatous. Multiple lymphomatous polyposis of the gastrointestinal tract scielo. Multiple lymphomatous polyposis mlp is an uncommon type of gastrointestinal lymphoma. Multiple lymphomatous polyposis of the gastrointestinal tract department of pathology and department of gastroenterological surgery, hospital do servidor publico estadual, sao paulo, brazil context. We report a rare case of multiple lymphomatous polyposis of the gastrointestinal tract in which the patient presented with abdominal pain and bloody diarrhea. The gastrointestinal tract is the predominant site of appearance of extranodal nonhodgkin lymphomas.
A rare case of multiple lymphomatous polyposis due to mantle cell lymphoma is reported in a 34yearold man. One case had multiple relapses despite treatment and died after 58 months. Multiple lymphomatous polyposis form is common but not specific for mantle cell lymphoma in the gastrointestinal tract. A limited partnership consists of a general partner, who manages the venture, and limited partners, who simply provide capital. The commonest gastrointestinal gi manifestation is multiple lymphomatous polyposis, in which multiple lymphoid polyps are present in the gi. Primary gastrointestinal tcell lymphoma resembling.
Mantlecell lymphoma multiple lymphomatous polyposis of. Pdf mantle cell lymphoma presenting as multiple lymphomatous. Multiple lymphomatous polyposis of the gastrointestinal tract can be associated with the bcell lymphoma variant, mantle cell lymphoma, with most cases having been described in patients who are more than 50 yearsofage. Multiple lymphomatous polyposis mlp is a distinctive type of primary gastrointestinal lymphoma characterized by polypoid accumulations of lymphoma tissue involving long segments of the gastrointestinal tract.
Patients range from 37 to 83 years of age, with a male predominance. Mantlecell lymphoma multiple lymphomatous polyposis of the. The condition has a characteristic pathological appearance and immunophenotype which is important in allowing distinction from other less aggressive forms of gastrointestinal. Multiple lymphomatous polyposis of the gastrointestinal tract. Complete response in a patient with colonic mantle. Multiple lymphomatous polyposis lp is a rare entity, characterized by multiple polypoid tu mors involving several segments of the gastrointestinal tract. Multiple lymphomatous polyposis of the colon and rectum. Master limited partnership master limited partnership a limited partnership with ownership units that may be traded on an exchange. In this large retrospective series of 12 pa tients with lp, histologic and immunohistochemical fea tures. Multiple lymphomatous polyposis is a distinctive and rare type of malignant gi lymphoma. A 78 years old patient was admitted to our department of general surgery with rectal bleeding, abdominal pain and weight loss.
Multiple lymphomatous polyposis is a rare type of gastrointestinal lymphoma that extensively infiltrates the intestine. Cell proliferation may be nodular or diffuse with a mixed nodular pattern. Multiple lymphomatous polyposis mlp is an uncom mon type of primary nonhodgkin gastrointestinal gi b cell lymphoma characterized by the presence of. Multiple lymphomatous polyposis is an uncommon but distinctive form of gastrointestinal lymphoma. Small bowel followup examination with barium shows multiple smooth and round. Extensive colorectal lymphomatous polyposis complicated by. Extensive colorectal lymphomatous polyposis complicated by acute. A master limited partnership allows limited partners to buy and sell units of the. In this large retrospective series of 12 patients with lp, histologic and immunohistochemical features were investigated from patients with multiple biopsy samples from each site.
Multiple lymphomatous polyposis mlp is an uncom mon type of primary non hodgkin gastrointestinal gi b cell lymphoma characterized by the presence of. An extensive histopathologic and immunohistochemical study of 12 cases. Asymptomatic multiple lymphomatous polyposis identified during. Multiple lymphomatous polyposis article about multiple. Most cases occur at multiple sites from oesophagus to rectum. Extranodal involvement of the gi tract is a wellrecognized entity of mantle cell lymphoma.
Biopsy was performed again to confirm the diagnosis of colonic mcl. Lymphomatous polyposis lp is a distinct clinicopathologic condition. This is a rare gastrointestinal nonhodgkin lymphoma forming numerous polyps. Exhaustive staging and immunohistochemical analysis were performed. We report a rare case of multiple lymphomatous polyposis of the gastrointestinal tract in which the patient. Ileocecal resection was performed on immunohistochemical examination, the. A case of mantle cell lymphoma mcl associated with multiple lymphomatous polyposis mlp is reported is a 62yearold woman, with special reference to the patients clinical features and response to treatment. Multiple lymphomatous polyposis is thought to represent mantle cell lymphoma of the gi tract. Lymphomatous definition of lymphomatous by the free dictionary. Multiple lymphomatous polyposis mlp as an extranodal manifestation of mantle cell lymphoma mcl in the.
Lymphomatous definition of lymphomatous by the free. Diffuse large bcell lymphoma presenting as multiple. Multiple lymphomatous polyposis is a rare form of gastrointestinal lymphoma characterized by the presence of multiple polyps throughout the length of the digestive tract. He received daily 100 mg of aspirin, enalapril maleate. Clinical symptoms may closely resemble those of colorectal carcinoma and diagnostic confusion may result. Multiple lymphomatous polyposis lp is a rare entity, characterized by multiple polypoid tumors involving several segments of the gastrointestinal tract. The gastrointestinal tract is the predominant site of extranodal nonhodgkin lymphomas. Arch pathol lab medvol 127, august 2003 multiple lymphomatous polyposisremestroche et al 1029 figure 1. In this large retrospective series of 12 pa tients with lp, histologic and immunohistochemical fea tures were investigated from patients with multiple bi. Multiple lymphomatous polyposis with diffuse involvement of. Multiple lymphomatous polyposis financial definition of. Ileocecal resection was performed on immunohistochemical.
Multiple lymphomatous polyposis mlp is uncommon and is regarded as the intestinal form of mcl. Multiple lymphomatous polyposis can present with diverse clinical symptoms including abdominal pain, diarrhea, bleeding, proteinlosing. Pdf multiple lymphomatous polyposis of the gastrointestinal. In fact tumor cells, typically, express cd20 or cd5 and cyclin d1 markers in these conditions. Malignant cells of mlp have mantle cell characteristics and thus are considered to be the counterpart of the mantle cell lymphoma mcl in the gi tract. Both patients had multiple polypoidal defects involving large segments of gastrointestinal tract.
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